New Microscope Images Individual Neurons Over A Large Field-Of-View
The new two-photon microscope, Diesel2p, was developed by UCSB researchers in the lab of Spencer LaVere Smith
Researchers in the lab of Spencer LaVere Smith, associate professor in UCSB's Department of Electrical & Computer Engineering, have developed a new two-photon microscope, the Diesel2p, capable of imaging individual neurons at an unprecedented scale. The technique allows for imaging many individual neurons at cellular-scale resolution across multiple brain regions. The findings are reported in the Nov. 17 issue of Nature Communications.
“We’re optimizing for three things: resolution to see individual neurons, a field of view to capture multiple brain regions simultaneously, and imaging speed to capture changes in neuron activity during behavior,” Smith explained. “The events that we’re interested in imaging last less than a second, so we don’t have time to move the microscope; we have to get everything in one shot, while still making sure that the optics can focus ultrafast pulses of laser light.”
Read more about this powerful new technology here in the full press release by James Badham in The Current.
